• BTEC Short Courses: Introduction to Design of Experiments (DoE) for Bioprocess Analysis and Optimization

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    Name: BTEC Short Courses: Introduction to Design of Experiments (DoE) for Bioprocess Analysis and Optimization
    Date: September 22, 2020 - September 24, 2020
    Event Description:

    Why should you attend?

    To learn the fundamental principles of Design of Experiments (DoE) methods applied to analysis and optimization of bioprocesses. DoE is critical to defining the design space for a process, which is central to the quality by design concepts presented in the ICH Guideline for Development and Manufacture of Drug Substances Q11. This course focuses on the application of DoE methods through the use of JMP statistical software, bioprocess case studies, and hands-on laboratory activities. The case studies, which focus on microbial fermentation and provide real data, look at the effects of factors such as medium components, induction temperature and time on microbial growth and protein (product) production.

    Attend and you will learn

    • Basic statistical concepts required for DoE; these include hypothesis testing, confidence intervals, statistical models and Analysis of Variance (ANOVA)
    • How to design and analyze experiments for the characterization and optimization of bioprocesses using factorial, fractional factorial, and response surface design concepts
    • How to interpret the output of experimental design software—for example, normal probability, interaction, contour and residual analysis plots or ANOVA tables for factorial or surface response models
    • How to use the popular JMP software in designing and analyzing experiments

    Who should attend

    The course is targeted to all those interested in bioprocess development and optimization, particularly those new to DoE techniques, including:

    • Bioprocess development scientists and engineers
    • Process validation staff interested in defining operating ranges and attribute specifications
    • Other professionals with previous hands-on bioprocess experience who want to learn about DoE

    Attend and you will receive

    • 21.5 hours of instruction (2.1 Continuing Education Units)
    • Notebook containing all course lecture and lab materials
    • Morning break
    • Lunch
    • Afternoon break
    • Certificate of attendance
    All courses are offered on site at BTEC, other than online courses. The Golden LEAF BTEC building is located at 850 Oval Drive on NC State University's Centennial Campus.
    Date/Time Information:
    September 22-24
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